PT  - JOURNAL ARTICLE
AU  - van Duijnhoven, Fränzel J B
AU  - Bueno-De-Mesquita, H Bas
AU  - Calligaro, Miriam
AU  - Jenab, Mazda
AU  - Pischon, Tobias
AU  - Jansen, Eugène H J M
AU  - Frohlich, Jiri
AU  - Ayyobi, Amir
AU  - Overvad, Kim
AU  - Toft-Petersen, Anne Pernille
AU  - Tjønneland, Anne
AU  - Hansen, Louise
AU  - Boutron-Ruault, Marie-Christine
AU  - Clavel-Chapelon, Françoise
AU  - Cottet, Vanessa
AU  - Palli, Domenico
AU  - Tagliabue, Giovanna
AU  - Panico, Salvatore
AU  - Tumino, Rosario
AU  - Vineis, Paolo
AU  - Kaaks, Rudolf
AU  - Teucher, Birgit
AU  - Boeing, Heiner
AU  - Drogan, Dagmar
AU  - Trichopoulou, Antonia
AU  - Lagiou, Pagona
AU  - Dilis, Vardis
AU  - Peeters, Petra H M
AU  - Siersema, Peter D
AU  - Rodríguez, Laudina
AU  - González, Carlos A
AU  - Molina-Montes, Esther
AU  - Dorronsoro, Miren
AU  - Tormo, Maria-Jose
AU  - Barricarte, Aurelio
AU  - Palmqvist, Richard
AU  - Hallmans, Göran
AU  - Khaw, Kay-Tee
AU  - Tsilidis, Kostas K
AU  - Crowe, Francesca L
AU  - Chajes, Veronique
AU  - Fedirko, Veronika
AU  - Rinaldi, Sabina
AU  - Norat, Teresa
AU  - Riboli, Elio
TI  - Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition
AID  - 10.1136/gut.2010.225011
DP  - 2011 Aug 01
TA  - Gut
PG  - 1094--1102
VI  - 60
IP  - 8
4099  - http://gut.bmj.com/content/60/8/1094.short
4100  - http://gut.bmj.com/content/60/8/1094.full
SO  - Gut2011 Aug 01; 60
AB  - Objective To examine the association between serum concentrations of total cholesterol, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol, triglycerides, apolipoprotein A-I (apoA), apolipoprotein B and the incidence of colorectal cancer (CRC).Design Nested case–control study.Setting The study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort of more than 520 000 participants from 10 western European countries.Participants 1238 cases of incident CRC, which developed after enrolment into the cohort, were matched with 1238 controls for age, sex, centre, follow-up time, time of blood collection and fasting status.Main outcome measures Serum concentrations were quantitatively determined by colorimetric and turbidimetric methods. Dietary and lifestyle data were obtained from questionnaires. Conditional logistic regression models were used to estimate incidence rate ratios (RRs) and 95% CIs which were adjusted for height, weight, smoking habits, physical activity, education, consumption of fruit, vegetables, meat, fish, alcohol, fibre and energy.Results After adjustments, the concentrations of HDL and apoA were inversely associated with the risk of colon cancer (RR for 1 SD increase of 16.6 mg/dl in HDL and 32.0 mg/dl in apoA of 0.78 (95% CI 0.68 to 0.89) and 0.82 (95% CI 0.72 to 0.94), respectively). No association was observed with the risk of rectal cancer. Additional adjustment for biomarkers of systemic inflammation, insulin resistance and oxidative stress or exclusion of the first 2 years of follow-up did not influence the association between HDL and risk of colon cancer.Conclusions These findings show that high concentrations of serum HDL are associated with a decreased risk of colon cancer. The mechanism behind this association needs further elucidation.