RT Journal Article
SR Electronic
T1 Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 1094
OP 1102
DO 10.1136/gut.2010.225011
VO 60
IS 8
A1 van Duijnhoven, Fränzel J B
A1 Bueno-De-Mesquita, H Bas
A1 Calligaro, Miriam
A1 Jenab, Mazda
A1 Pischon, Tobias
A1 Jansen, Eugène H J M
A1 Frohlich, Jiri
A1 Ayyobi, Amir
A1 Overvad, Kim
A1 Toft-Petersen, Anne Pernille
A1 Tjønneland, Anne
A1 Hansen, Louise
A1 Boutron-Ruault, Marie-Christine
A1 Clavel-Chapelon, Françoise
A1 Cottet, Vanessa
A1 Palli, Domenico
A1 Tagliabue, Giovanna
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Vineis, Paolo
A1 Kaaks, Rudolf
A1 Teucher, Birgit
A1 Boeing, Heiner
A1 Drogan, Dagmar
A1 Trichopoulou, Antonia
A1 Lagiou, Pagona
A1 Dilis, Vardis
A1 Peeters, Petra H M
A1 Siersema, Peter D
A1 Rodríguez, Laudina
A1 González, Carlos A
A1 Molina-Montes, Esther
A1 Dorronsoro, Miren
A1 Tormo, Maria-Jose
A1 Barricarte, Aurelio
A1 Palmqvist, Richard
A1 Hallmans, Göran
A1 Khaw, Kay-Tee
A1 Tsilidis, Kostas K
A1 Crowe, Francesca L
A1 Chajes, Veronique
A1 Fedirko, Veronika
A1 Rinaldi, Sabina
A1 Norat, Teresa
A1 Riboli, Elio
YR 2011
UL http://gut.bmj.com/content/60/8/1094.abstract
AB Objective To examine the association between serum concentrations of total cholesterol, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol, triglycerides, apolipoprotein A-I (apoA), apolipoprotein B and the incidence of colorectal cancer (CRC).Design Nested case–control study.Setting The study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort of more than 520 000 participants from 10 western European countries.Participants 1238 cases of incident CRC, which developed after enrolment into the cohort, were matched with 1238 controls for age, sex, centre, follow-up time, time of blood collection and fasting status.Main outcome measures Serum concentrations were quantitatively determined by colorimetric and turbidimetric methods. Dietary and lifestyle data were obtained from questionnaires. Conditional logistic regression models were used to estimate incidence rate ratios (RRs) and 95% CIs which were adjusted for height, weight, smoking habits, physical activity, education, consumption of fruit, vegetables, meat, fish, alcohol, fibre and energy.Results After adjustments, the concentrations of HDL and apoA were inversely associated with the risk of colon cancer (RR for 1 SD increase of 16.6 mg/dl in HDL and 32.0 mg/dl in apoA of 0.78 (95% CI 0.68 to 0.89) and 0.82 (95% CI 0.72 to 0.94), respectively). No association was observed with the risk of rectal cancer. Additional adjustment for biomarkers of systemic inflammation, insulin resistance and oxidative stress or exclusion of the first 2 years of follow-up did not influence the association between HDL and risk of colon cancer.Conclusions These findings show that high concentrations of serum HDL are associated with a decreased risk of colon cancer. The mechanism behind this association needs further elucidation.