RT Journal Article
SR Electronic
T1 Effectiveness of one-time endoscopic screening programme in prevention of upper gastrointestinal cancer in China: a multicentre population-based cohort study
JF Gut
JO Gut
FD BMJ Publishing Group Ltd and British Society of Gastroenterology
SP 251
OP 260
DO 10.1136/gutjnl-2019-320200
VO 70
IS 2
A1 Chen, Ru
A1 Liu, Yong
A1 Song, Guohui
A1 Li, Bianyun
A1 Zhao, Deli
A1 Hua, Zhaolai
A1 Wang, Xinzheng
A1 Li, Jun
A1 Hao, Changqing
A1 Zhang, Liwei
A1 Liu, Shuzheng
A1 Wang, Jialin
A1 Zhou, Jinyi
A1 Zhang, Yongzhen
A1 Li, Bo
A1 Li, Yanyan
A1 Feng, Xiang
A1 Li, Lin
A1 Dong, Zhiwei
A1 Wei, Wenqiang
A1 Wang, Guiqi
YR 2021
UL http://gut.bmj.com/content/70/2/251.abstract
AB Objectives To estimate the effectiveness of endoscopic screening programme in reducing incidence and mortality of upper gastrointestinal cancer in high risks areas of China.Design This multicentre population-based cohort study was conducted in six areas in China from 2005 to 2015. All permanent residents aged 40 to 69 years were identified as target subjects. We refer to those who were invited for screening collectively as the invited group. Of these, we classify those who were invited and undertook endoscopic screening as the screened group and those who were invited but did not accept screening as the non-screened group. Target subjects who were not invited to the screening were assigned to the control group. The effectiveness of the endoscopic screening and screening programme were evaluated by comparing reductions in incidence and mortality from upper gastrointestinal cancer in the screened and invited group with control group.Results Our cohort analysis included 637 500 people: 299 483 in the control group and 338 017 in the invited to screening group, 113 340 (33.53%) of whom were screened eventually. Compared with subjects in the control group, upper gastrointestinal cancer incidence and mortality decreased by 23% (relative risk (RR)=0.77, 95% CI 0.74 to 0.81) and 57% (RR=0.43, 95% CI 0.40 to 0.47) in the screened group, respectively, and by 14% (RR=0.86, 95% CI 0.84 to 0.89) and 31% (RR=0.69, 95% CI 0.66 to 0.72) in the invited group, respectively.Conclusion Among individuals aged 40 to 69 years in high risk areas of upper gastrointestinal cancer, one-time endoscopic screening programme was associated with a significant decrease in upper gastrointestinal cancer incidence and mortality.