Frequency of the homozygous OCTN-TC haplotype and of the homozygous IGR2078a_1AA genotype stratified by clinical phenotype of Crohn’s disease
| Subgroup | No of individuals (n = 412) | Frequency of the TC haplotype (%) | Significance v controls (p value*; OR (95% CI) | Frequency of IGR2078a_1A (%) | Significance v controls (p value*; OR (95% CI) |
|---|---|---|---|---|---|
| *p values given were significant (p<0.05), also after application of Bonferroni’s correction. †Data were also analysed for isolated fistulising or fibrostenotic disease behaviour but no further significant association was noted. | |||||
| Disease location | |||||
| Ileal and no colonic | 50 | 10.0 | NS | 8.0 | NS |
| Colonic and no ileal | 62 | 33.9 | 0.0008; 2.61 (1.45–4.68) | 31.7 | 0.0032; 2.45 (1.32–4.50) |
| Any colonic disease | 360 | 26.1 | <0.0001; 1.80 (1.34–2.43) | 23.9 | 0.0016; 1.66 (1.20–2.28) |
| Disease behaviour | |||||
| Any fistulising† | 223 | 23.8 | NS | 21.5 | NS |
| Any fibrostenotic† | 262 | 24.4 | NS | 21.4 | NS |
| Non-fistulising non-fibrostenotic | 92 | 27.2 | NS | 26.1 | NS |
| Need for surgery | |||||
| Ileocaecal resection | 144 | 22.9 | NS | 21.5 | NS |
| No ileocaecal resection | 268 | 25.0 | 0.0016; 1.70 (1.21–2.37) | 22.4 | NS |