Table 2

Area under the curve with 95% CIs achieved by the imCMS classifier trained by domain adversarial training

(A) FOCUS
CMS3× (n slides=510, n patients=278)
Model 1Model 2Model 3Model 4Model 5Overall
CMS10.85 (0.77 to 0.96)0.78 (0.64 to 0.93)0.95 (0.91 to 1)0.89 (0.82 to 0.97)0.83 (0.72 to 0.97)0.86 (0.81 to 0.92)
CMS20.9 (0.85 to 0.97)0.96 (0.93 to 1)0.93 (0.89 to 0.98)0.9 (0.84 to 0.97)0.87 (0.8 to 0.94)0.91 (0.88 to 0.93)
CMS30.89 (0.81 to 1.02)0.98 (0.97 to 1.01)0.81 (0.67 to 1.01)0.96 (0.92 to 0.99)0.91 (0.86 to 0.99)0.92 (0.88 to 0.98)
CMS40.89 (0.84 to 0.99)0.9 (0.83 to 0.98)0.88 (0.82 to 0.97)0.89 (0.81 to 0.99)0.91 (0.86 to 0.97)0.89 (0.87 to 0.93)
Macro-average0.88 (0.83 to 0.95)0.9 (0.86 to 0.95)0.89 (0.83 to 0.95)0.91 (0.87 to 0.94)0.88 (0.84 to 0.93)0.9 (0.87 to 0.91)
(B) TCGA
CMS3× (n slides=431, n patients=430)
Model 1Model 2Model 3Model 4Model 5Ensemble
CMS10.84 (0.79 to 0.91)0.87 (0.83 to 0.92)0.84 (0.78 to 0.91)0.82 (0.77 to 0.89)0.82 (0.75 to 0.88)0.85 (0.8 to 0.9)
CMS20.88 (0.85 to 0.91)0.87 (0.83 to 0.91)0.87 (0.84 to 0.91)0.83 (0.79 to 0.88)0.83 (0.8 to 0.87)0.89 (0.85 to 0.92)
CMS30.82 (0.76 to 0.88)0.76 (0.7 to 0.82)0.76 (0.7 to 0.83)0.76 (0.67 to 0.82)0.73 (0.66 to 0.81)0.78 (0.71 to 0.85)
CMS40.84 (0.79 to 0.87)0.84 (0.8 to 0.88)0.8 (0.76 to 0.85)0.81 (0.77 to 0.86)0.8 (0.75 to 0.85)0.83 (0.78 to 0.87)
Macro-average0.84 (0.81 to 0.87)0.83 (0.8 to 0.86)0.82 (0.78 to 0.85)0.8 (0.77 to 0.84)0.79 (0.76 to 0.83)0.84 (0.8 to 0.87)
(C) GRAMPIAN
CMS12× (n slides=265, n patients=144)
Model 1Model 2Model 3Model 4Model 5Ensemble
CMS10.79 (0.71 to 0.87)0.63 (0.51 to 0.74)0.78 (0.66 to 0.87)0.84 (0.77 to 0.93)0.87 (0.82 to 0.95)0.87 (0.81 to 0.94)
CMS20.83 (0.78 to 0.89)0.73 (0.67 to 0.78)0.73 (0.67 to 0.8)0.75 (0.68 to 0.81)0.77 (0.71 to 0.83)0.79 (0.74 to 0.84)
CMS30.84 (0.78 to 0.89)0.73 (0.65 to 0.81)0.76 (0.68 to 0.83)0.77 (0.72 to 0.83)0.8 (0.74 to 0.87)0.8 (0.75 to 0.86)
CMS40.92 (0.88 to 0.96)0.84 (0.78 to 0.91)0.87 (0.81 to 0.95)0.92 (0.88 to 0.98)0.94 (0.9 to 0.98)0.93 (0.89 to 0.98)
Macro-average0.84 (0.82 to 0.88)0.73 (0.69 to 0.79)0.78 (0.75 to 0.82)0.82 (0.78 to 0.86)0.85 (0.81 to 0.88)0.85 (0.82 to 0.89)

  • CMS, consensus molecular subtype ; TCGA, The Cancer Genome Atlas.