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Targeting tumour-intrinsic N7-methylguanosine tRNA modification inhibits MDSC recruitment and improves anti-PD-1 efficacy

Authors

  • Haining Liu Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Xuezhen Zeng Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Xuxin Ren Department of Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Yifan Zhang Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Manling Huang Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China Department of Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Li Tan Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Zihao Dai Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Jiaming Lai Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Wenxuan Xie Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Zebin Chen Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Sui Peng Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China Clinical Trials Unit, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China Department of Gastroenterology and Hepatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Lixia Xu Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China Department of Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Shuling Chen Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China Division of Interventional Ultrasound, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Shunli Shen Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Ming Kuang Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China Sun Yat-sen University Zhongshan School of Medicine, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Shuibin Lin Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Shuibin Lin, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; linshb6{at}mail.sysu.edu.cn; Professor Ming Kuang, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; kuangm{at}mail.sysu.edu.cn; Professor Shunli Shen, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; shenshli{at}mail.sysu.edu.cn
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Citation

Liu H, Zeng X, Ren X, et al
Targeting tumour-intrinsic N7-methylguanosine tRNA modification inhibits MDSC recruitment and improves anti-PD-1 efficacy

Publication history

  • Received February 21, 2022
  • Accepted October 7, 2022
  • First published October 25, 2022.
Online issue publication 
October 18, 2023

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