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Original research
Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade

Authors

  • Claire Conche Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt/Main, Germany PubMed articlesGoogle scholar articles
  • Fabian Finkelmeier Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt/Main, Germany Department of Medicine I, Gastroenterology, Hepatology and Endocrinology, Goethe University Frankfurt, Frankfurt/Main, Germany PubMed articlesGoogle scholar articles
  • Marina Pešić Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt/Main, Germany PubMed articlesGoogle scholar articles
  • Adele M Nicolas Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt/Main, Germany PubMed articlesGoogle scholar articles
  • Tim W Böttger Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt/Main, Germany PubMed articlesGoogle scholar articles
  • Kilian B Kennel Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt/Main, Germany PubMed articlesGoogle scholar articles
  • Dominic Denk Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt/Main, Germany Department of Medicine I, Gastroenterology, Hepatology and Endocrinology, Goethe University Frankfurt, Frankfurt/Main, Germany PubMed articlesGoogle scholar articles
  • Fatih Ceteci Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt/Main, Germany PubMed articlesGoogle scholar articles
  • Kathleen Mohs Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt/Main, Germany PubMed articlesGoogle scholar articles
  • Esther Engel Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt/Main, Germany PubMed articlesGoogle scholar articles
  • Özge Canli Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany PubMed articlesGoogle scholar articles
  • Yasamin Dabiri Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt/Main, Germany PubMed articlesGoogle scholar articles
  • Kai-Henrik Peiffer Department of Medicine I, Gastroenterology, Hepatology and Endocrinology, Goethe University Frankfurt, Frankfurt/Main, Germany PubMed articlesGoogle scholar articles
  • Stefan Zeuzem Department of Medicine I, Gastroenterology, Hepatology and Endocrinology, Goethe University Frankfurt, Frankfurt/Main, Germany PubMed articlesGoogle scholar articles
  • Gabriela Salinas University Medical Center Göttingen (UMG), Institute of Human Genetics, NGS- Integrative Genomics Core Unit (NIG), Göttingen, Germany PubMed articlesGoogle scholar articles
  • Thomas Longerich Institute of Pathology, UniversitätsKlinikum Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Huan Yang Center for Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA PubMed articlesGoogle scholar articles
  • Florian R Greten Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Frankfurt/Main, Germany Frankfurt Cancer Institute, Goethe University Frankfurt, Frankfurt/Main, Germany German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Florian R Greten, Institute for Tumor Biology and Experimental Therapy, Frankfurt/Main 60596, Germany; greten{at}gsh.uni-frankfurt.de
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Citation

Conche C, Finkelmeier F, Pešić M, et al
Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade

Publication history

  • Received May 21, 2022
  • Accepted January 7, 2023
  • First published January 27, 2023.
Online issue publication 
February 16, 2024

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